Methods

Grading system

The quality of the evidence and the strength of the recommendations are categorized according to a 4-level color schema adapted from existing level of evidence criteria.
We use an adapted version of the ‘‘Applying classification of recommendations and level of evidence’’ criteria of the American Heart Association and of the Grading of Recommendations Assessment Development and Evaluation (GRADE) criteria of the GRADE working group.*

* Kremer LCM, Mulder RL, Oeffinger KC, et al. A worldwide collaboration to harmonize guidelines for the long-term follow-up of childhood and young adult cancer survivors: A report from the International Late Effects of Childhood Cancer Guideline Harmonization Group. Pediatr. Blood Cancer 2013;60:543–549. Copyright © 2012 Wiley Periodicals, Inc. This material is reproduced with permission of John Wiley & Sons, Inc.